2nd ed. Parkinson disease. View abstract. Arzneimittelforschung. Nephrol.Dial.Transplant. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. J Clin Pharmacol 2006;46:201-13. View abstract. 1998;48(3):236-239. Z Gastroenterol 2001;39(7):511-7. Hepatology 2000;32(5):897-900. Strahlenther.Onkol. Biochemical and clinical effects of whey protein supplementation in Parkinson's disease: A pilot study. Mushroom poisoning. Asghar, Z. and Masood, Z. 2012;95(1-2):67-72. Skottova, N. and Krecman, V. Silymarin as a potential hypocholesterolaemic drug. Pade, D. and Stavchansky, S. Selection of bioavailability markers for herbal extracts based on in silico descriptors and their correlation to in vitro permeability. Dig Liver Dis 2004;36:752-9. Zhang, J. Q., Mao, X. M., and Zhou, Y. P. [Effects of silybin on red blood cell sorbitol and nerve conduction velocity in diabetic patients]. 40 Tropfen (2 ml) … Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. Moayedi B, Gharagozloo M, Esmaeil N, et al. 10-10-1980;92(19):678-683. Carduus marianus L.) Familie. Milk thistle might decrease how quickly the liver breaks down some medications. Adverse reaction: milk thistle-associated toxicity. Szilard S, Szentgyorgyi D, Demeter I. Marcelli R, Bizzoni P, Conte D, and et al. 40 Tropfen (2 ml) … View abstract. Research on the effects of milk thistle in people with hepatitis B is not consistent. Kiesewetter, E., Leodolter, I., and Thaler, H. [Results of two double-blind studies on the effect of silymarine in chronic hepatitis (author's transl)]. Eur J Haematol 2013;90(3):202-9. Kassenarzt 1990;33:36-41. Sonnenbichler J and Zetl I. 2017;18(2). Early research shows that milk thistle taken for 6 weeks does not reduce the symptoms of hair pulling. 2010;18(5):385-386. Silybum marianum pericarp yields enhanced silymarin products. Planta Med 1980;38(3):227-237. View abstract. View abstract. Early research shows that taking milk thistle by mouth might improve liver function and reduce risk of death. But these markers aren't always linked with the NAFLD severity. High cholesterol. View abstract. Acne. auch geeignet fÜr schwangere frauen und kinder. Taking milk thistle might affect how well the liver breaks down drugs. Build-up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Batakov, E. A. View abstract. Silymarin 200 mg taken orally three times/day in … Silybum marianum. Early research shows that applying a specific product containing the milk thistle extract reduces the effect of radiation on the skin in women being treated for breast cancer. 2011;9(1):1-6. 2011;30(1):38-43. View abstract. BMC Complement Altern Med. Evaluation of the galactogogue effect of silymarin on mothers of preterm newborns (<32 weeks). Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. View abstract. AUCH GEEIGNET FÜR SCHWANGERE FRAUEN UND KINDER. Oz) Silybum Marianum . 2017;31(9):1323-29. J Hepatol. Medications used for lowering cholesterol (Statins) interacts with MILK THISTLE. Tóth B, Németh D, Soós A, et al. Acta Med Hung 1988;45:249-56. View abstract. Boerth J, Strong KM. Skin toxicity caused by radiation. View abstract. Giorgi, V. S., Peracoli, M. T., Peracoli, J. C., Witkin, S. S., and Bannwart-Castro, C. F. Silibinin modulates the NF-kappab pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women. 7-14-1978;73(28-29):1060-1065. Die Mariendistel ist eine dekorative Gartenpflanze, und sollte in keinem Heilpflanzengarten fehlen. Some of these medications changed by the liver include acetaminophen, atorvastatin (Lipitor), diazepam (Valium), digoxin, entacapone (Comtan), estrogen, irinotecan (Camptosar), lamotrigine (Lamictal), lorazepam (Ativan), lovastatin (Mevacor), meprobamate, morphine, oxazepam (Serax), and others. MADE IN ITALY. Palasciano G, Portincasa P, Palmieri V, and et al. View abstract. Int J Clin Pharmacol Ther 2002;40(1):2-8. Velussi M, Cernigoi AM, Viezzoli L, and et al. View abstract. 2020;9(3):1707-11. View abstract. EINE NATÜRLICHE HILFE: MARIENDISTEL Nahrungsergänzungsmittel in Tropfen. Comoglio, A., Tomasi, A., Malandrino, S., Poli, G., and Albano, E. Scavenging effect of silipide, a new silybin-phospholipid complex, on ethanol-derived free radicals. 2004;3(2):201-206. Milk Thistle (Silybum marianum) is an herb traditionally used for maintaining healthy liver function. 100 % NATÜRLICH, ALKOHOLFREI, OHNE ZUCKERZUSATZ. BEIM ITALIENISCHEN GESUNDHEITSMINISTERIUM GEMELDET. Therapeutic effects of silymarin]. View abstract. There is evidence that milk thistle extract improves markers of liver injury in people with NAFLD. A randomized clinical pilot study. Stimulating influence of a flavonolignane derivative on proliferation, RNA synthesis and protein synthesis in liver cells. Silybum Marianum Extract Market Regional overview: In the report, experts analyze and forecast the Silybum Marianum Extract market on a global as well as regional level. EXTRACT OF LADY'S THISTLE FRUIT, EXTRACT OF SILYBUM MARIANUM FRUIT, LADY'S THISTLE (SILYBUM … Silybum Marianum Extract ist ein Extrakt aus Samen und Blättern der Mariendistel, Silybum marianum, Asteraceae INCI-Funktion hautpflegend Die INCI-Funktion beschreibt lediglich den Verwendungszweck eines Kosmetik-Inhaltsstoffs. 40 Tropfen (2 ml) … 40 Tropfen (2 ml) … View abstract. Silybum marianum seed extract was successfully used for the single-pot biosynthesis of spherical AgNPs in ambient conditions with the size range from 1 to 25 nm, as inferred from the TEM imaging. 2014;42(10):1611-6. View abstract. certified organic cane alcohol (62 … A placebo-controlled double blind study]. PLoS.One. Schrieber, S. J., Wen, Z., Vourvahis, M., Smith, P. C., Fried, M. W., Kashuba, A. D., and Hawke, R. L. The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity. Yakoot, M. and Salem, A. Spirulina platensis versus silymarin in the treatment of chronic hepatitis C virus infection. Phytomedicine 2013;21:75-81. Actas Dermosifiliogr. This information may not fit your specific health circumstances. J Clin Psychopharmacol 2019;39(2):129-34. doi: 10.1097/JCP.0000000000001005. BEIM ITALIENISCHEN GESUNDHEITSMINISTERIUM GEMELDET. Sie kann auch gut als Kübelpflanze gezogen werden. View abstract. MARIENDISTEL (Silybum marianum) Früchte URTINKTUR KONZENTRIERT EXTRAKT 1:10. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury. 1-11-2009;150(2):73-79. Phytomedicine 2000;7:273-82. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes. El-Kamary, S. S., Shardell, M. D., Abdel-Hamid, M., Ismail, S., El-Ateek, M., Metwally, M., Mikhail, N., Hashem, M., Mousa, A., Aboul-Fotouh, A., El-Kassas, M., Esmat, G., and Strickland, G. T. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis. EINE NATÜRLICHE HILFE: MARIENDISTEL Nahrungsergänzungsmittel in Tropfen. Study on dose-linearity of the pharmacokinetics of silibinin diastereomers using a new stereospecific assay. Download as PDF. Zhang, J., Luan, Q., Liu, Y., Lee, D. Y., and Wang, Z. Effect of Silibinin on biliary lipid composition. View abstract. Milk thistle is a weed, which grows commonly in California and other parts of the world having a warm climate. FDA letter to GCI Nutrients Worldwide Inc. February 16, 2005. View abstract. EINE NATÜRLICHE HILFE: MARIENDISTEL Nahrungsergänzungsmittel in Tropfen. Mol.Pharm. Taking milk thistle might lessen acne severity. AUCH GEEIGNET FÜR SCHWANGERE FRAUEN UND KINDER. This could increase or decrease how well some of these medications work. Hepatology. Swelling (inflammation) of the liver caused by the hepatitis C virus (hepatitis C). Early research shows that taking a combination supplement containing milk thistle extract can improve mental function and increase disease stabilization in people with multiple sclerosis. 1997;15(1):27-33. MARIENDISTEL (Silybum marianum) Früchte URTINKTUR KONZENTRIERT EXTRAKT 1:10. Some preliminary research … De Martiis, M., Fontana, M., Assogna, G., D'Ottavi, R., and D'Ottavi, O. View abstract. Mirnezami M, Jafarimanesh H, Rezagholizamenjany M, et al. MADE IN ITALY. Planta Med 1984;50(3):248-250. Medicinal herbs: modulation of estrogen action. View abstract. View abstract. Sonnenbichler J, Scalera F, Sonnenbichler I, Weyhenmeyer R. Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells. 2009;16(5):391-400. PLoS One. Grant JE and Odlaug BL. View abstract. Milk thistle might help the body break down estrogen pills to get rid of them. EINE NATÜRLICHE HILFE: MARIENDISTEL Nahrungsergänzungsmittel in Tropfen. Swelling (inflammation) and build up of fat in the liver in people who drink little or no alcohol (nonalcoholic steatohepatitis or NASH). View abstract. Protection against microcystin-LR-induced hepatotoxicity by Silymarin: biochemistry, histopathology, and lethality. A bioavailability cross-over randomised study on silybin. van Erp NP, Baker SD, Zhao M, et al. Drug Metab Dispos. MARIENDISTEL (Silybum marianum) Früchte URTINKTUR KONZENTRIERT EXTRAKT 1:10. Flory, P. J., Krug, G., Lorenz, D., and Mennicke, W. H. [Studies on elimination of silymarin in cholecystectomized patients. Rotem C, Kaplan B. Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study. Methods Find.Exp Clin Pharmacol 1981;3(2):71-77. View abstract. Kim DH, Jin YH, Park JB, Kobashi K. Silymarin and its components are inhibitors of beta-glucuronidase. View abstract. View abstract. Country of origin: USA, Europe. Int.J Clin Pharmacol Ther Toxicol 1992;30(4):134-138. This could increase or decrease how well these medications work. Taking into … View abstract. Milk thistle might decrease hormones in the body. Biochem.Pharmacol 6-15-1985;34(12):2209-2212. This milk thistle extract has been shown to reduce lipid peroxidation and inhibit fibrogenesis in rodent animal models, 225,226 as well as in … Milk thistle extracts inhibit the oxidation of low-density lipoprotein (LDL) and subsequent scavenger receptor-dependent monocyte adhesion. Eur Urol 2005;48(6):922-930. SILYBUM MARIANUM AKA Milk Thistle is a herb that is in the daisy family and has been used over 2,000 years in Europe for herbal remedies. View abstract. Derosa G, D'Angelo A, Maffioli P. The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus. Piscitelli SC, Formentini E, Burstein AH, et al. View abstract. J Hepatol 1998;28:615-21. Bioimpedance analysis, metabolic effects and safety of the association Berberis aristata/Bilybum marianum: a 52-week double-blind, placebo-controlled study in obese patients with type 2 diabetes. Zhonghua Gan Zang.Bing.Za Zhi. It does not appear to more beneficial than conventional medication. Becker-Schiebe, M., Mengs, U., Schaefer, M., Bulitta, M., and Hoffmann, W. Topical use of a silymarin-based preparation to prevent radiodermatitis : results of a prospective study in breast cancer patients. 2019;69(11):630-638. So, it's not clear if the cholesterol reduction is due to milk thistle or the statin-like chemicals. Early research shows that taking milk thistle extract by mouth for up to one year, or taking a product containing the milk thistle constituent silybin plus phosphatidylcholine by mouth for 1 week, improves liver function tests. All rights reserved. 1994;32(11):614-617. Silybum marianum, also called milk thistle, is an annual or biannual plant belonging to the Asteraceae family. 2018;44:39-44. Clin Gastroenterol Hepatol. Before taking milk thistle talk to your healthcare provider if you take any medications that are changed by the liver. 40 Tropfen (2 ml) … 2015;29(7):1046-53. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. About the Experts. Iran J.Diabetes Lipid Disord. 2011;6(1):e16464. The effect of milk thistle on liver damage caused by chemicals is inconsistent. View abstract. Aliment Pharmacol Ther 2004;20:1279-87. Aliment Pharmacol Ther 2011;33:127-37. Liver scarring (cirrhosis). $14.45. Orv.Hetil. Valenzuela, A., Lagos, C., Schmidt, K., and Videla, L. A. Silymarin protection against hepatic lipid peroxidation induced by acute ethanol intoxication in the rat. View abstract. This survey is being conducted by the WebMD marketing sciences department. Diabetes Metab Syndr Obes. Biol Pharm Bull 1994;17:443-5. Dermatol Ther. Silibinin, a semipurified fraction of silymarin, is primarily a mixture of 2 diastereoiso… Feher J, Deak G, Muzes G, et al. Iran J.Diabetes Lipid Disord. Effect of addition of silymarin to renin-angiotensin system inhibitors on proteinuria in type 2 diabetic patients with overt nephropathy: a randomized, double-blind, placebo-controlled trial. Elyasi S, Hosseini S, Niazi Moghadam MR, Aledavood SA, Karimi G. Effect of Oral Silymarin Administration on Prevention of Radiotherapy Induced Mucositis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. Weyhenmeyer, R., Mascher, H., and Birkmayer, J. Magliulo, E., Gagliardi, B., and Fiori, G. P. [Results of a double blind study on the effect of silymarin in the treatment of acute viral hepatitis, carried out at two medical centres (author's transl)]. Nanoparticles containing silymarin derivatives were prepared from de-oiled silybum marianum seeds extract using supercritical CO 2 (SC-CO 2) and DMSO.All steps including lipophilic compounds removal, extraction, and particle production were carried out using SC-CO 2.In This method, SC-CO 2 was saturated with the solution of the extract at higher pressure. This agent may also promote the growth of new hepatic cells. Current Therapeutic Research 1994;55(5):537-545. The clinical trial of Silybum Marianum seed extract (Silymarin) on type II diabetic patients with hyperlipidemia. 9-9-1975;64(36):1145-1151. Milk Thistle Treatment for Children and Adults with Trichotillomania: A Double-Blind, Placebo-Controlled, Crossover Negative Study. 2020;31(3):256-60. View abstract. Tiwari, P., Kumar, A., Balakrishnan, S., Kushwaha, H. S., and Mishra, K. P. Silibinin-induced apoptosis in MCF7 and T47D human breast carcinoma cells involves caspase-8 activation and mitochondrial pathway. It also seems to help the liver in people who take isotretinoin for acne or drugs for tuberculosis. View abstract. Br J Cancer 1996;74(12):2036-2041. BEIM ITALIENISCHEN GESUNDHEITSMINISTERIUM GEMELDET. 2015;22(2):231-7. Ann Mtg Digestive Disease Week 1999 May. Free shipping . Home; All Herbs; Milk Thistle; Milk Thistle Benefits. View abstract. 2016;35(5):1091-5. c) Dry extract (DER 20-70:1), extraction solvent acetone 2009;68(1):47-60. Inflamm.Allergy Drug Targets. Cell Biochem Funct. View abstract. Gatti, G. and Perucca, E. Plasma concentrations of free and conjugated silybin after oral intake of a silybin-phosphatidylcholine complex (silipide) in healthy volunteers. Silybum marianum (milk thistle) fruit extract. Related terms: Methotrexate; Silibinin; Vitamin E; Cisplatin; Vitamin C; Doxorubicin; Flavonoid; Glycyrrhetinic Acid Phospholipid Complex; Silymarin; Cytochrome P450 3A4; View all Topics . Adverse Drug Reactions Advisory Committee. Gharagozloo, M., Moayedi, B., Zakerinia, M., Hamidi, M., Karimi, M., Maracy, M., and Amirghofran, Z. Silybum marianum extract A mixture of flavonolignans isolated from the milk thistle plant Silybum marianum. Wagoner, J., Morishima, C., Graf, T. N., Oberlies, N. H., Teissier, E., Pecheur, E. I., Tavis, J. E., and Polyak, S. J. Early research shows that applying a gel containing milk thistle extract to the hands and feet beginning on the first day of chemotherapy and continuing for 9 weeks decreases the severity of this skin reaction caused by cancer drug treatment. Milk Thistle (Silybum marianum) Liver Support Vitamins & Minerals, Milk Thistle (Silybum marianum) Detox Vitamins & Minerals, Milk Thistle (Silybum marianum) Extract Vitamins & Minerals, Milk Thistle … Phytother Res. Analysis and comparison of active constituents in commercial standardized silymarin extracts by liquid chromatography-electrospray ionization mass spectrometry. Medicine (Baltimore) 2018;97(37):e12243. Bunout D, Hirsch S, Petermann M. [Controlled study of the effect of silymarin on alcoholic liver disease.] View abstract. 1991;12(3):290-295. View abstract. View abstract. Prostate cancer. Anon. MADE IN ITALY. View abstract. Effect of milk thistle on the pharmacokinetics of indinavir in healthy volunteers. Lang, I., Deak, G., Nekam, K., Muzes, G., Gonzalez-Cabello, R., Gergely, P., and Feher, J. Hepatoprotective and immunomodulatory effects of antioxidant therapy. Locher, R., Suter, P. M., Weyhenmeyer, R., and Vetter, W. Inhibitory action of silibinin on low density lipoprotein oxidation. Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures. Support: +49(0)89-69374504 , Mo-Fr 9-16 h/9am-4pm Velussi M, Cernigoi AM, De Monte A, et al. As scientists who evolve with technology we treat innovation as a way of life, a life we dedicate to improvement and advancement of Safety, Health and Environment. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. 2012;60(6):896-903. Ebrahimpour-Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. Silymarin treatment of obsessive-compulsive spectrum disorders. Free Radical Res Commun 1987;4(125):129. Huseini HF, Larijani B, Heshmat R, et al. Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. 2015;8:89-96. View abstract. Chin J Integr Med. View abstract. (Syn. Silybum marianum extract secondary reference standard; CAS Number: 84604-20-6; EC Number: 283-298-7; Synonym: Milk thistle extract; find null-05135001 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. J Agric Food Chem 6-11-2008;56(11):3966-3972. Am J Med 10-15-2002;113(6):506-515. BEIM ITALIENISCHEN GESUNDHEITSMINISTERIUM GEMELDET. Silybum marianum, commonly known as Milk thistle, has been used to support liver health for over 2000 years. Brinda, B. J., Zhu, H. J., and Markowitz, J. S. A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma. View abstract. … Anticancer Res 2010;30:79-85. Milk Thistle naturally contains about 70 - 80% Silymarin (and many other constituents thought to work in harmony). Some research shows that taking milk thistle extract by mouth along with the allergy medication cetirizine (Zyrtec) reduces seasonal allergies more than taking cetirizine alone. Biochem.Pharmacol 10-12-1995;50(8):1313-1316. Randomized controlled study of the efficacy and tolerability of a short course of IdB 1016 in the treatment of chronic persistent hepatitis. Paula Begoun is the best-selling author of 20 books about skincare and makeup. Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP. Diese und andere Eigenschaften finden Sie nachfolgend. Hair pulling (trichotillomania). View abstract. MADE IN ITALY. Silymarin use and liver disease progression in the hepatitis C Antiviral Long-Term Treatment against Cirrhosis Trial. 2015;35(3):340-2. Prostate 6-1-2010;70(8):848-855. pii: E343. Inability to become pregnant within a year of trying to conceive (infertility). However, it is hard to obtain silibinin in the US. Rating: Best; Categories: Plant Extracts, Antioxidants; See lady's thistle (milk thistle) extract Back to Ingredient Dictionary. A., Reiberger, T., Rutter, K., Beinhardt, S., Staettermayer, A. F., Peck-Radosavljevic, M., and Ferenci, P. Successful HCV eradication and inhibition of HIV replication by intravenous silibinin in an HIV-HCV coinfected patient. Schriewer, H. and Rauen, H. M. [The effect of silybin dihemisuccinate on cholesterol biosynthesis in rat liver homogenates (author's transl)]. Where did you or where do you plan to purchase this product? Malekshah RE, Khaleghian A. Katiyar, S. K., Korman, N. J., Mukhtar, H., and Agarwal, R. Protective effects of silymarin against photocarcinogenesis in a mouse skin model. Chalasani N, Younossi Z, Lavine JE, et al. 2004;3(2):201-206. Anon. Herbal preparation(s) a) Comminuted herbal substance b) Powdered herbal substance . Research shows that taking a specific combination product containing milk thistle and other ingredients by mouth for 3 months reduces hot flashes by 73% and night sweats by 69% in people with menopausal symptoms. Influence of Legalon(TM) 140 on the metabolism of collagen in patients with chronic liver disease--Review by measurement of PIIINP-values. Arzneimittelforschung. Multiple sclerosis (MS). View abstract. Wien.Klin.Wochenschr. Available at: https://www.ahrq.gov/clinic/epcsums/milktsum.htm. AUCH GEEIGNET FÜR SCHWANGERE FRAUEN UND KINDER. View abstract. 5-1-2010;50(9):520-528. JAMA 7-18-2012;308(3):274-282. View abstract. MARIENDISTEL (Silybum marianum) Früchte URTINKTUR KONZENTRIERT EXTRAKT 1:10. Protective effect of Legalon in workers exposed to organic solvents. Boari, C., Montanari, F. M., Galletti, G. P., Rizzoli, D., Baldi, E., Caudarella, R., and Gennari, P. [Toxic occupational liver diseases. Inflammation and ulcers (mucositis) caused by radiation. View abstract. View abstract. Vailati A, Aristia L, Sozze E, and et al. Therapiewoche 1985;35:3375-3378. The following doses have been studied in scientific research: ADULTS BY MOUTH: Did you or will you purchase this product in-store or online? AUCH GEEIGNET FÜR SCHWANGERE FRAUEN UND KINDER. AUCH GEEIGNET FÜR SCHWANGERE FRAUEN UND KINDER. J.Clin.Virol. View abstract. Ferenci P, Dragosics B, Dittrich H, et al. 2015;21(12):902-6. Silymarin may act as an antioxidant, protecting hepatic cells from chemotherapy-related … 1976;26(1):69-73. 2017 Jan;28(1):4-15. Alzheimer disease. Nat.Prod.Commun. A comparison of the diastereoisomers, silybin A and silybin B, on the induction of apoptosis in K562 cells. Sonnenbichler, J. and Zetl, I. Biochemical effects of the flavonolignane silibinin on RNA, protein and DNA synthesis in rat livers. 1996;11(1):55-62. View abstract. Di Pierro F, Bellone I, Rapacioli G, Putignano P. Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins. Grungreiff K, Albrecht M, and Strenge-Hesse A. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine. But taking a product containing the milk thistle constituent silybin plus phosphatidylcholine by mouth for 2 weeks to 3 months might improve some liver function tests. View abstract. Report of a controlled trial (author's transl)]. 2014;941085. doi: 10.1155/2014/941085. Barzaghi, N., Crema, F., Gatti, G., Pifferi, G., and Perucca, E. Pharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjects. Med Sci Ress 1995;23:31-33. View abstract. Vidlar, A., Vostalova, J., Ulrichova, J., Student, V., Krajicek, M., Vrbkova, J., and Simanek, V. The safety and efficacy of a silymarin and selenium combination in men after radical prostatectomy - a six month placebo-controlled double-blind clinical trial. Beckmann-Knopp S, Rietbrock S, Weyhenmeyer R, et al. View abstract. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial.